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Document Fiscal Period Focus Document Fiscal Period Focus Entity Shell Company Entity Shell Company Other Other Accrued Liabilities, Current Cash and Cash Equivalents, at Carrying Value, Total Cash and cash equivalents Cash and Cash Equivalent Weighted Average Number of Shares Outstanding Reconciliation [Abstract] Weighted-average common shares outstanding (note 9): Rule10B 51Trading Plan [Member] Rule10B 51Trading Plan [Member] Rule10B 5-1 Trading Plan [Member] Research and Development Arrangement, Contract to Perform for Others, Type Research and Development Arrangement, Contract to Perform for Others, Type [Axis] Cybersecurity Risk Management, Strategy, and Governance [Abstract] Common shares, Issued Common Stock, Shares, Issued Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag] Cybersecurity Risk Board of Directors Oversight [Text Block] Operating lease, description Lessee, Operating Lease, Description Asset Class [Domain] Asset Class Statement [Table] Statement [Table] Dr. Gary Patou [Member] Dr. Gary Patou. Weighted average fair value of stock options granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Statement [Line Items] Statement [Line Items] Cashless exercise of stock options Cashless Exercise Of Stock Options Number of share options (or share units) exercised via net exercise (cashless) method during the current period. Warrants Warrant [Member] Entity Filer Category Entity Filer Category Total liabilities and shareholders’ equity Liabilities and Equity Payables and Accruals [Abstract] Gross proceeds from issuable of common stock. Gross Proceeds From Issuable Of Common Stock Gross proceeds from issuable of common stock Purchases of marketable securities Payments to Acquire Marketable Securities Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Weighted Average Exercise Price, Exercisable, End of period Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period Increase In Operating Lease Liability And Accounts Receivable Related To Lease Incentives Claimed In The Period Increase in operating lease liability and accounts receivable related to lease incentives claimed in the period. First renewal option. 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Significant Accounting Policies Significant Accounting Policies [Text Block] ATM [Member] At Market Equity Offering At Market Equity Offering [Member] At -the -market equity offering. Future potential payments Future Potential Milestone Payments Future potential milestone payments. Number of Options, Granted Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Cybersecurity Risk Management, Strategy, and Governance [Table] Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of Basic and Diluted Net Loss Per Common Share Common Stock Issued For Pre Funded Warrants Common stock issued for pre-funded warrants. Common stock issued for pre-funded warrants Other receivables Increase (Decrease) in Other Receivables Other receivables Lessee Operating Lease Liability Payments Due After Year Four Amount of lessee's undiscounted obligation for lease payment for operating lease due after fourth fiscal year following current fiscal year. Excludes interim and annual periods when interim periods are reported from current statement of financial position date (rolling approach). 2031 and thereafter Earnings Per Share, Basic, Total Basic Earnings Per Share, Basic Net loss per common share - basic Number of Options Outstanding, Beginning balance Number of Options Outstanding, Ending balance Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Lease term and discount rate: Lease Term And Discount Rate [Abstract] Lease Term And Discount Rate. Total current liabilities Liabilities, Current Issuance of common shares and pre-funded warrants, net Stock Issuance Of Common Shares And Pre-Funded Warrants Net Stock issuance of common shares and pre-funded warrants net. Shareholders’ equity: Equity, Attributable to Parent [Abstract] Needham Massachusetts [Member] Needham Massachusetts. Entity Small Business Entity Small Business Retained Earnings (Accumulated Deficit), Total Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Convertible Preferred Shares [Member] Preferred Stock [Member] Shares price Sale of Stock, Price Per Share Organization, Consolidation and Presentation of Financial Statements [Abstract] Lease Contractual Term [Axis] Lease Contractual Term [Axis] Leases [Abstract] Lessee Lease Description [Line Items] Lessee, Lease, Description [Line Items] Amendment Flag Amendment Flag Liabilities and shareholders’ equity Liabilities and Equity [Abstract] Azetukalner [Member] Azetukalner. Azetukalner Entity Address, Postal Zip Code Entity Address, Postal Zip Code Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Increase (Decrease) in Operating Lease Liability Operating lease liability Pain Programs (XEN1701, XEN1120) [Member] Pain Programs (XEN1701, XEN1120). Pain programs (XEN1701, XEN1120) Gillian Cannon [Member] Gillian Cannon. Common Shares [Member] Common Stock [Member] Cybersecurity Risk Role of Management [Text Block] Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Weighted Average Exercise Price, Granted Lessee, Operating Lease, Liability, to be Paid, Year Three 2029 Schedule Of Available For Sale Securities [Line Items] Debt Securities, Available-for-Sale [Line Items] Research and Development Arrangement, Contract to Perform for Others, Type Research and Development Arrangement, Contract to Perform for Others, Type [Domain] Entity Address, Address Line One Entity Address, Address Line One Fair Value Assumptions for Stock Options Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] Earnings Per Share [Abstract] Net loss per common share (note 9): Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag] Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash paid: Operating Lease, Right-of-Use Asset Operating lease right-of-use asset, net (note 5) Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block] OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total Unrealized gain (loss) on available-for-sale securities (note 4) Document Type Document Type Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Entity Central Index Key Entity Central Index Key Debt Securities, Available-for-Sale [Table Text Block] Summary of Amortized Cost, Unrealized Gain (Loss) Recognized in AOCI and Fair Value of Available-for-Sale Securities Investments, Debt and Equity Securities [Abstract] Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block] Warrants issued price per pre funded warrant. Warrants Issued Price Per Pre Funded Warrant Price per Pre-Funded Warrant Warrants issued price per pre funded warrant Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Increase (decrease) in cash and cash equivalents Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Potentially dilutive outstanding securities (in shares) Stock-based compensation expense APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition Operating Lease, Right-of-Use Asset, Periodic Reduction Non-cash operating lease expense Increase (Decrease) in Other Operating Liabilities Increase (Decrease) in Other Operating Liabilities, Total Other liabilities Amortized Cost Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost Fair Value Trading securities available-for-sale Fair Value Marketable securities Cash, money market fund, mutual funds, commercial paper and U.S. treasuries. 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Common shares (weighted average) Shares exercised Number of Options, Exercised Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Exercise of stock options (in Shares) Accrued Liabilities, Current Total accrued liabilities Current Fiscal Year End Date Current Fiscal Year End Date Document Quarterly Report Document Quarterly Report Entity Address, State or Province Entity Address, State or Province Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Number of Shares, Beginning balance Number of Shares, Ending balance J P Morgan Securities LLC Jefferies LLC Td Securities USA LLC Stifel Nicolaus And Company Incorporated RBC Capital Markets LLC And William Blair And Company L L C J P Morgan Securities LLC Jefferies LLC Td Securities USA LLC Stifel Nicolaus And Company Incorporated RBC Capital Markets LLC And William Blair And Company L L C [Member] J p Morgan securities LLC jefferies LLC td securities USA LLC stifel nicolaus and company incorporated RBC capital markets LLC and William blair and company l l c. Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Common Stock, Capital Shares Reserved for Future Issuance Common stock, capital shares reserved for future issuance (in shares) Geographical Geographical [Axis] Preferred shares, converted Conversion of Stock, Shares Converted Marketable Securities, Current Marketable securities (note 5) Other General and Administrative Expense Other general and administrative costs Accounts Payable, Trade, Current Accounts payable Stock Based Compensation Expenses Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options Collaborative Arrangement Disclosure [Text Block] Collaboration Revenue Performance Shares [Member] Performance Share Units (PSUs) PSUs Second renewal option. Second Renewal Option [Member] Second Renewal Option [Member] Deferred tax assets Deferred Income Tax Assets, Net Proceeds from marketable securities Proceeds from Sale and Maturity of Marketable Securities Common shares reserved for issuance Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized Stock option activity. Stock Option Activity [Abstract] Contractual maturity of 0 to 1 years, Fair Value Fair Value Debt Securities, Available-for-Sale, Current Fair Value, Current Antidilutive Securities [Axis] Contractual maturity of 1 to 3 years, Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost, Noncurrent Amortized Cost, Non-current Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract] Related Party Transaction Related Party Transaction [Axis] AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Loss [Member] Minimum [Member] Weighted Average Grant Date Fair Value, Granted Weighted Average Grant Date Fair Value, Granted Weighted average grant date fair value Financial Instrument Financial Instrument [Axis] Current assets: Assets, Current [Abstract] Warrants outstanding to purchase common stock Pre-Funded Warrants to Purchase Common Shares Class of Warrant or Right, Number of Securities Called by Each Warrant or Right Level 3 [Member] Fair Value, Inputs, Level 3 [Member] Segment Reporting [Abstract] Schedule of Financial Assets Measured at Fair Value on a Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Current liabilities: Liabilities, Current [Abstract] Balance (in Shares) Balance (in Shares) Shares, Outstanding Accounts Receivable, after Allowance for Credit Loss, Current, Total Accounts receivable Accounts Receivable, after Allowance for Credit Loss, Current Lessee, Operating Lease, Renewal Term Operating lease extension term Prepaid expenses, long-term Prepaid Expense, Noncurrent Prepaid Expense, Noncurrent, Total Commitments and Contingencies Commitments and contingencies (note 10) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Weighted Average Grant Date Fair Value, Beginning balance Weighted Average Grant Date Fair Value, Ending balance Operating Lease, Liability, Total Present value of lease liabilities Operating Lease, Liability Common Stock, No Par Value Common shares, without par value Ian Mortimer [Member] Ian Mortimer. Marketable Securities, Noncurrent Marketable securities, long-term (note 4) Lessee Lease Description [Table] Lessee, Lease, Description [Table] Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total Net loss Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Lease Contractual Term [Domain] Lease Contractual Term [Domain] Cybersecurity Risk Management Positions or Committees Responsible [Text Block] Weighted Average Number of Shares Outstanding, Basic, Total Basic Weighted Average Number of Shares Outstanding, Basic Weighted average common shares outstanding - basic Schedule of Weighted Average Remaining Lease Term and Discount Rate [Table Text Block] Schedule of weighted average remaining lease term and discount rate. Schedule of Weighted Average Remaining Lease Term and Discount Rate Segment Reporting, Expense Information Used by CODM, Description Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block] 2025 Inducement Equity Incentive Plan Two Thousand Twenty Five Inducement Equity Incentive Plan [Member] Two Thousand Twenty Five Inducement Equity Incentive Plan. Burnaby, British Columbia [Member] Burnaby British Columbia [Member] Burnaby, British Columbia. Total shareholders' equity Balance Balance Equity, Attributable to Parent Statement of Stockholders' Equity [Abstract] Stock Options exercised for Number of Common Shares for cash Stock Options Exercised For Number Of Common Shares For Cash Number of share options (or share units) exercised for number of common shares for cash during the period. Schedule of Quantitative Information About Operating Leases [Table Text Block] Schedule of Quantitative Information About Operating Leases Schedule of Quantitative Information About Operating Leases Over-Allotment Option [Member] Foreign exchange gain Foreign Currency Transaction Gain (Loss), before Tax, Total Gain (Loss), Foreign Currency Transaction, before Tax Foreign exchange gain Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Supplemental disclosures of non-cash transactions: Noncash Investing and Financing Items [Abstract] Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration] Segment Reporting, Other Segment Item, Amount Other segment items Plan Name [Domain] Regulatory Milestone [Member] Regulatory Milestone [Member] Regulatory milestone. Financial Assets Measured at Fair Value on a Recurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block] Cybersecurity Risk Management Expertise of Management Responsible [Text Block] March 2021 Pre Funds Warrants Outstanding Date Issuance March Two Thousand Twenty One [Member] Pre funds warrants outstanding date issuance march two thousand twenty one. Cash received for lease incentives Cash received for lease incentives. Outstanding, beginning Class of Warrant or Right, Outstanding Outstanding, ending Lessee, Operating Lease, Liability, Payment, Due [Abstract] Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract] Related Party Related and Nonrelated Parties [Axis] Marketable Security, Realized Gain (Loss) Realized (gain) loss on marketable securities Interest Receivable and Accretion Of Discounts On Marketable Securities Interest Receivable and Accretion Of Discounts On Marketable Securities Interest receivable and accretion of discounts on marketable securities Entity Address, City or Town Entity Address, City or Town Common stock issued for cashless exercise Common Stock Issued For Cashless Exercise Number of common stock issued in exchange for share options (or share units) exercised via net exercise (cashless) method during the current period. Number of Reportable Segments Number of reportable segments Security Exchange Name Security Exchange Name Available for sale debt securities accumulated gross unrealized gain (loss) before tax. Available For Sale Debt Securities Accumulated Gross Unrealized Gain (Loss) Before Tax Unrealized Gain (Loss) Counterparty Name Counterparty Name [Axis] Loss before income taxes Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Antidilutive Securities, Name [Domain] Stockholders' Equity Note [Abstract] Royalty obligations Royalty Obligations Royalty obligations. Statistical Measurement Statistical Measurement [Domain] Neurocrine Biosciences [Member] Neurocrine Biosciences [Member] Neurocrine biosciences. Exercise Price Warrants exercise price per common share Class of Warrant or Right, Exercise Price of Warrants or Rights Total current assets Assets, Current Share-Based Payment Arrangement, Expense Total stock-based compensation Document Period End Date Document Period End Date Other Income and Expenses [Abstract] Other income: Title and Position [Axis] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Domain] Number of Options Exercisable, End of period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Exercise of pre-funded warrants Stock Issued During Period Value Conversion Of Pre Funded Warrant Stock issued during period value conversion of pre funded warrant. Statement of Financial Position [Abstract] Restricted Stock Units (RSUs) [Member] Restricted share units (RSUs) RSUs Antidilutive Security, Excluded EPS Calculation [Table] Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Class of Stock Class of Stock [Axis] Fair value assumptions for stock options. Fair Value Assumptions For Stock Options [Abstract] BVF Partners L.P [Member] B V F Partners L P [Member] BVF Partners L P. Fair value of pre-funded warrants exercised Fair value of pre-funded warrants exercised Fair Value Of Pre-funded Warrants Exercised Cybersecurity Risk Management, Strategy, and Governance [Line Items] Total liabilities Liabilities Financial Instruments Financial Instruments [Domain] Lessee, Operating Lease, Liability, to be Paid, Year Two 2028 Cash and Cash Equivalents and Marketable Securities, Fair Value Disclosure Cash and cash equivalents and marketable securities, fair value disclosure. Cash and cash equivalents and marketable securities Weighted Average Number of Shares Outstanding, Diluted, Total Diluted Weighted Average Number of Shares Outstanding, Diluted Weighted average common shares outstanding - diluted Entity File Number Securities Act File Number Basis of Presentation Basis of Accounting [Text Block] Cover [Abstract] Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total Increase (Decrease) in Accounts Payable and Accrued Liabilities Accounts payable and accrued liabilities Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Number of Shares, Forfreited Number of Shares, Forfreited Taxes Payable, Current Income and other taxes Taxes Payable, Current, Total Unrealized Gain (Loss), Foreign Currency Transaction, before Tax Unrealized foreign exchange (gain) loss U.S. Treasuries [Member] US Treasuries [Member] US Treasury Securities [Member] Sale of Stock Sale of Stock [Domain] Segment Reporting Disclosure [Text Block] Segment Disclosure General and administrative General and Administrative Expense, Total General and Administrative Expense Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Noncash Item [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Revenue from Contract with Customer, Including Assessed Tax Collaboration revenue Collaboration revenue (note 8) Number of Options, Forfeited, cancelled or expired Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Total New Accounting Pronouncements, Policy [Policy Text Block] Recent accounting pronouncements Future Minimum Lease Payments Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block] Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Vesting period Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount Unrecognized stock-based compensation cost to be achieved Employees and officers Employees And Officers [Member] Employees And Officers Other Receivables, Net, Current Other Receivables, Net, Current, Total Other receivables Operating lease term Lessee, Operating Lease, Term of Contract Common Stock, Shares, Outstanding, Ending Balance Common Stock, Shares, Outstanding, Beginning Balance Common shares, Outstanding Common Stock, Shares, Outstanding Operating Lease, Liability, Current Operating lease liability (note 5) Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] Cybersecurity Risk Management Processes Integrated [Flag] Document Transition Report Document Transition Report Total operating expenses Operating Expenses Accrued liabilities Accrued Liabilities, Current [Abstract] Research and Development Expense Research and Development Expense, Total Research and development Direct external research and development costs Leases Lessee, Operating Leases [Text Block] Contractual maturity of 0 to 1 years, Amortized Cost Debt Securities, Available-for-Sale, Amortized Cost, Current Amortized Cost, Current Statement of Cash Flows [Abstract] Stock Issued During Period, Value, New Issues Issuance of common shares, net of issuance costs (note 9a) Issuance of common shares and pre-funded warrants, net Stock Option Activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Trading marketable securities Debt Securities, Trading Share Capital Equity [Text Block] Net cash increase in operating and investing activities Net Cash Increase in Operating and Investing Activities Net cash increase in operating and investing activities Earnings Per Share [Text Block] Net Loss Per Common Share Cybersecurity Risk Management Processes Integrated [Text Block] Net loss Net loss Net loss for the period Proceeds from offerings, net Proceeds From Offerings, Net Proceeds from offerings, net. Operating lease expense Operating Lease, Cost Expected dividend yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Debt securities available for sale accumulated gross unrealized gain (loss) before tax current Debt Securities Available For Sale Accumulated Gross Unrealized Gain (Loss) Before Tax Current Unrealized Gain (Loss), Current Operating Lease, Payments Operating lease Assets Assets [Abstract] Average risk-free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Document Fiscal Year Focus Document Fiscal Year Focus June 2022 Pre Funds Warrants Outstanding Date Issuance June Two Thousand Twenty Two [Member] Pre funds warrants outstanding date issuance june two thousand twenty two. Investing activities: Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] Schedule of Basic and Diluted Net Loss Per Common Share Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table Text Block] 1st Order Pharmaceuticals, Inc. [Member] First Order Pharmaceuticals Inc [Member] 1st Order Pharmaceuticals, Inc. Marketable Securities Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block] Lessee operating lease number of renewal options. Lessee Operating Lease Number of Renewal Options Operating lease, number of renewal options Proceeds from exercise of stock options Proceeds from Stock Options Exercised Rule10B 51Trading Plan One [Member] Rule10B 51Trading Plan One [Member] Rule10B 5-1 Trading Plan One [Member] Fair Value Disclosures [Abstract] Commitments and Contingencies Disclosure [Abstract] Lessee, Operating Lease, Liability, to be Paid, Year One 2027 License and Collaboration Agreement. License And Collaboration Agreement [Member] License and Collaboration Agreement [Member] Share-Based Payment Arrangement [Abstract] Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total Unrecognized stock-based compensation cost not to be achieved Debt Securities, Trading, Unrealized Gain (Loss) Debt Securities, Trading, Unrealized Gain (Loss), Total Unrealized fair value gain on trading securities Unrealized fair value gain on trading securities Financial assets Assets, Fair Value Disclosure, Total Assets, Fair Value Disclosure Jefferies and Stifel [Member] Jefferies L L C And Stifel Nicolaus Company Incorporated [Member] Jefferies LLC and Stifel, Nicolaus & Company, Incorporated member. Jefferies LLC and Stifel, Nicolaus & Company, Incorporated [Member] Sale of Stock Sale of Stock [Axis] Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Schedule of RSU activity Jefferies, Stifel, J.P. Morgan Securities LLC and SVB Securities LLC [Member] Jefferies L L C Stifel Nicolaus Company Incorporated J P Morgan Securities L L C And S V B Securities L L C [Member] Jefferies L L C, Stifel Nicolaus Company Incorporated, J.P.Morgan Securities LLC and SVB Securities LLC. Share Capital [Table] Share Capital [Table] Share capital. Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash provided by (used in) investing activities Weighted Average Number Of Prefunded Warrants Weighted average number of prefunded warrants. Pre-funded warrants (weighted average) Title of 12(b) Security Title of 12(b) Security Schedule of Segment Reporting Information, by Segment [Table] Milestone Revenue Milestone revenue Milestone revenue Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Weighted Average Grant Date Fair Value, Forfeited Related Party Related and Nonrelated Parties [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Lessee, Operating Lease, Liability, to be Paid, Remainder of Fiscal Year 2026 Series 1 Preferred Shares Series 1 Preferred Shares Series1 Preferred Shares [Member] Series 1 preferred shares. Other liabilities, long-term Other Liabilities, Noncurrent Changes in operating assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Weighted Average Exercise Price Outstanding, Beginning of period Weighted Average Exercise Price Outstanding, End of period Schedule Of Pre Funded Warrants Activity [Table Text Block] Schedule of pre funded warrants activity. Schedule of Pre-Funded Warrants Activity Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table] Fair Value, Recurring and Nonrecurring [Table] Additional Paid-in Capital [Member] Additional Paid-in Capital [Member] Measurement Frequency Measurement Frequency [Domain] Change in Accounting Principle, Accounting Standards Update, Adoption Date Accounting standards update, adopted date Trading Symbol Trading Symbol Directors Director [Member] Employee-related Liabilities, Current, Total Employee compensation, benefits, and related accruals Employee-related Liabilities, Current Financing activities: Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Average expected term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Fair Value, Recurring [Member] Recurring Basis [Member] Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accounts Payable and Accrued Liabilities Total future minimum lease payments Lessee, Operating Lease, Liability, to be Paid Less: imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Equity Components Equity Components [Axis] Nonoperating Income (Expense) Total other income Equity Component Equity Component [Domain] Asset Class Asset Class [Axis] Shares Issued, Value, Share-Based Payment Arrangement, before Forfeiture Issuance of common shares pursuant to equity incentive plans Depreciation, Depletion and Amortization, Nonproduction, Total Depreciation, Depletion and Amortization, Nonproduction Depreciation of property plant and equipment Accounts and other receivable Accounts and Other Receivables, Net, Current Maximum [Member] Maximum [Member] PreFunds Warrants Outstanding Date Issuance March Two Thousand Twenty Four [Member] PreFunds Warrants Outstanding Date Issuance March Two Thousand Twenty Four [Member] March 2024 Statistical Measurement Statistical Measurement [Axis] Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Weighted Average Exercise Price, Exercised Common Stock, Value, Issued Common shares, without par value; unlimited shares authorized; issued and outstanding: 96,624,123 (December 31, 2025 - 80,010,790) (note 7) Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block] Pre-clinical, discovery and other programs Pre-clinical Discovery And Other Programs [Member] Pre-clinical discovery and other programs. Expected volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Entity Registrant Name Entity Registrant Name Milestone payment paid Milestone Payments Paid Milestone payments paid. Debt securities available for sale accumulated gross unrealized gain (loss) before tax noncurrent. Debt Securities Available For Sale Accumulated Gross Unrealized Gain (Loss) Before Tax Noncurrent Contractual maturity of 1 to 3 years, Unrealized Gain (Loss) Unrealized Gain (Loss), Non-current Total Accounts Payable and Accrued Liabilities, Current Accounts payable and accrued liabilities (note 6) Cybersecurity Risk Management Positions or Committees Responsible [Flag] Income Tax Expense (Benefit), Total Income Tax Expense (Benefit) Income tax recovery (expense) Measurement Frequency Measurement Frequency [Axis] Sale proceeds of common shares Proceeds from Issuance of Common Stock Issuance of common shares, net of issuance costs (note 9a) Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Personnel Related Expenses Personnel related expenses. Personnel-related expenses Accumulated Other Comprehensive Income (Loss), Net of Tax, Total Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income (loss) Payments to Acquire Property, Plant, and Equipment, Total Purchases of property, plant and equipment Payments to Acquire Property, Plant, and Equipment Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Shares granted Number of Shares, Granted Total assets Assets Income Statement [Abstract] Share-Based Payment Arrangement [Policy Text Block] Stock-based compensation Deferred Income Tax Expense (Benefit), Total Deferred Income Tax Expense (Benefit) Deferred income tax expense (recovery) Cash Money Market Fund Mutual Funds And U.s. Treasuries Fair Value Disclosure Cash money market fund mutual funds and U.S. Treasuries fair value disclosure Cash and cash equivalents Shares issued Shares issued Issuance of common shares and pre-funded warrants, net Lease, Cost [Abstract] Lease cost: Change in Accounting Principle, Type [Extensible Enumeration] Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Shares vested Number of Shares, Vested Number of Shares, Vested Asset Purchase Agreement [Member] Asset Purchase Agreement [Member] Asset purchase agreement. Earnings Per Share, Diluted, Total Diluted Earnings Per Share, Diluted Net loss per common share - diluted Issued Number Of Warrants Issued Number of warrants issued. Schedule of Segment Reporting Information, by Segment [Table Text Block] Summary of Net Loss Related To Segment Expenses Title and Position [Domain] City Area Code City Area Code Other Comprehensive Income (Loss), Net of Tax Other Comprehensive Income (Loss), Net of Tax, Total Other comprehensive income (loss) Rule10B 51Trading Plan Two [Member] Rule10B 51Trading Plan Two [Member] Counterparty Name Counterparty Name [Domain] Variable lease expense Variable Lease, Cost Share Capital [Line Items] Share Capital [Line Items] Share capital. Weighted average remaining lease term (years) Operating Lease, Weighted Average Remaining Lease Term Segment Reporting Information [Line Items] Operating lease expiration date Lease Expiration Date Property, Plant and Equipment, Net, Total Property, plant and equipment, net Property, Plant and Equipment, Net Accrued Research and Development, Current Accrued research and development, current. Research and development Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total Cash and cash equivalents, beginning of period Cash and cash equivalents, end of period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation Loss from operations Operating Income (Loss) Accumulated Deficit [Member] Retained Earnings [Member] Interest received Interest Received Interest received. Entity Address, Country Entity Address, Country Share-Based Payment Arrangement, Noncash Expense, Total Share-Based Payment Arrangement, Noncash Expense Stock-based compensation expense Stock-based compensation expense Number of warrants exercised. Number Of Warrants Exercised Exercised Exercise of pre-funded warrants Weighted average discount rate Operating Lease, Weighted Average Discount Rate, Percent Operating Lease, Liability, Noncurrent Operating lease liability, long-term (note 5) Level 1 [Member] Fair Value, Inputs, Level 1 [Member] Class Of Stock [Line Items] Class of Stock [Line Items] Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash provided by financing activities Exchange Agreement [Member] Exchange Agreement [Member] Exchange agreement. Schedule of Cost Components of Operating Lease Lease, Cost [Table Text Block] Accounting standards update, adopted Change in Accounting Principle, Accounting Standards Update, Adopted [true false] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Summary of Potentially Dilutive Securities Corporate Debt Securities [Member] Corporate Debt Securities [Member] Debt Securities Available For Sale [Table] Debt Securities, Available-for-Sale [Table] Entity Interactive Data Current Entity Interactive Data Current Operating activities: Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Segment Reporting, Expense Information Used by CODM, Type [Extensible Enumeration] Commitments And Contingencies [Table] Commitments And Contingencies [Table] Commitments and contingencies. Entity Tax Identification Number Entity Tax Identification Number Number of operating leases Lessee Number Of Operating Leases Lessee, number of operating leases. Nature of the Business Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Effect of exchange rate changes on cash and cash equivalents Effect of Exchange Rate on Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Local Phone Number Local Phone Number Related Party Transaction Related Party Transaction [Domain] Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Weighted Average Number of Shares Outstanding, Basic [Abstract] Numerator: Accounting Policies [Abstract] Stock Issued During Period Shares Conversion Of Pre Funded Warrant Stock issued during period shares conversion of pre funded warrant. Exercise of pre-funded warrants (in shares) Prior Period Reclassification Adjustment Prior period reclassification adjustment Lessee, Operating Lease, Liability, to be Paid, Year Four 2030 Fair Value Of Stock Options Exercised On Cashless Basis The aggregate grant-date fair value of stock options exercised via net exercise (cashless) during the reporting period as calculated by applying the disclosed option pricing methodology. Fair value of stock options and pre-funded warrants exercised on a cashless basis Class of Stock Class of Stock [Domain] Commercial Paper [Member] Commercial Paper [Member] Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Unrecognized stock-based compensation expected to be recognized over a period Professional fees Accrued Professional Fees, Current Schedule of Accounts Payable and Accrued Liabilities [Table Text Block] Accounts Payable and Accrued Liabilities Schedule Of Stock By Class [Table] Stock, Class of Stock [Table] Common shares, shares authorized Common Stock, Shares Authorized, Unlimited [Fixed List] Entity Emerging Growth Company Entity Emerging Growth Company Commitments And Contingencies [Line Items] Commitments And Contingencies [Line Items] Commitments and contingencies. October 2021 Pre Funds Warrants Outstanding Date Issuance October Two Thousand Twenty One [Member] Pre funds warrants outstanding date issuance october two thousand twenty one.