100000 - Document - Document And Entity Information
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100010 - Statement - Consolidated Balance Sheets
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100020 - Statement - Consolidated Balance Sheets (Parenthetical)
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100030 - Statement - Consolidated Statements of Operations and Comprehensive Loss 2
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100040 - Statement - Consolidated Statements of Operations and Comprehensive Loss
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100050 - Statement - Consolidated Statements of Shareholders' Equity
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100060 - Statement - Consolidated Statements of Cash Flows
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100070 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995455 - Disclosure - Nature of the Business
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995465 - Disclosure - Basis of Presentation
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995475 - Disclosure - Significant Accounting Policies
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995485 - Disclosure - Changes in Significant Accounting Policies
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995495 - Disclosure - Fair Value of Financial Instruments
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995515 - Disclosure - Property, Plant and Equipment
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995525 - Disclosure - Leases
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995535 - Disclosure - Accounts Payable and Accrued Liabilities
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995545 - Disclosure - Term Loan
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995555 - Disclosure - Share Capital
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995565 - Disclosure - Concentrations of Market Risk
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995575 - Disclosure - Collaboration Agreements
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995585 - Disclosure - Net Loss Per Common Share
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995595 - Disclosure - Commitments and Contingencies
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995605 - Disclosure - Income Taxes
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995615 - Disclosure - Segment Disclosure
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995625 - Disclosure - Significant Accounting Policies (Policies)
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995635 - Disclosure - Significant Accounting Policies (Tables)
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995645 - Disclosure - Fair Value of Financial Instruments (Tables)
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995665 - Disclosure - Property, Plant and Equipment (Tables)
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995675 - Disclosure - Leases (Tables)
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995685 - Disclosure - Accounts Payable and Accrued Liabilities (Tables)
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995695 - Disclosure - Share Capital (Tables)
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995705 - Disclosure - Collaboration Agreements (Tables)
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995715 - Disclosure - Net Loss Per Common Share (Tables)
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995725 - Disclosure - Income Taxes (Tables)
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995735 - Disclosure - Segment Disclosure (Tables)
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995745 - Disclosure - Leases - Future Minimum Lease Payments (Details) 2
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995755 - Disclosure - Nature of the business (Details)
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995765 - Disclosure - Basis of Presentation (Details)
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995775 - Disclosure - Significant Accounting Policies - Property Plant and Equipment Estimated Useful Lives (Details)
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995785 - Disclosure - Significant Accounting Policies (Details)
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995795 - Disclosure - Changes in Significant Accounting Policies (Details)
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995805 - Disclosure - Fair Value of Financial Instruments - Schedule of Financial Assets Measured at Fair Value on a Recurring Basis (Details)
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995825 - Disclosure - Marketable Securities - Summary of Amortized Cost, Unrealized Gain (Loss) Recognized in AOCI and Fair Value of Available-for-Sale Securities (Details)
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995835 - Disclosure - Property, Plant and Equipment - Summary of Property, Plant and Equipment (Details)
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995845 - Disclosure - Leases (Details)
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995855 - Disclosure - Leases - Schedule of Cost Components of Operating Lease (Details)
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995865 - Disclosure - Leases - Future Minimum Lease Payments (Details)
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995875 - Disclosure - Accounts Payable and Accrued Liabilities - Accounts Payable and Accrued Liabilities (Details)
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995885 - Disclosure - Share Capital (Details)
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995895 - Disclosure - Share Capital - Stock Based Compensation Expenses (Details)
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995905 - Disclosure - Share Capital - Stock Option Activity (Details)
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995915 - Disclosure - Share Capital - Stock Option Activity (Parenthetical) (Details)
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995925 - Disclosure - Share Capital - Fair Value Assumptions for Stock Options (Details)
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995935 - Disclosure - Share Capital - Summary of UnVested Stock Option Activity (Details)
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995945 - Disclosure - Share Capital - Schedule of Pre-Funded Warrants (Details)
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995955 - Disclosure - Share capital - Schedule of Pre-Funded Warrants (Parenthetical) (Details)
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995965 - Disclosure - Concentrations of Market Risk (Details)
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995975 - Disclosure - Collaboration Agreements - Schedule of Collaboration Revenue (Details)
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995985 - Disclosure - Collaboration Agreements (Details)
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995995 - Disclosure - Net Loss Per Common Share - Schedule of Basic and Diluted Net Loss Per Common Share (Details)
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996005 - Disclosure - Net Loss Per Common Share - Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share (Details)
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996015 - Disclosure - Commitments and Contingencies (Details)
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996025 - Disclosure - Income Taxes - Schedule of Loss before Income Taxes (Details)
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996035 - Disclosure - Income Taxes - Schedule of Income Tax Recovery (Expense) (Details)
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996045 - Disclosure - Income Taxes (Details)
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996055 - Disclosure - Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details)
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996065 - Disclosure - Income Taxes - Schedule of Net Deferred Income Tax Assets (Details)
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996075 - Disclosure - Segment Disclosure - Additional Information (Details)
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996085 - Disclosure - Segment Disclosure - Summary of Net Loss Related To Segment Expenses (Details)
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Statement [Line Items]
Statement [Line Items]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Increase (Decrease) in Accounts Receivable
Accounts receivable
Plan Name [Domain]
Plan Name
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Office Equipment [Member]
Office Furniture and Equipment [Member]
Clinical developement and other milestone.
Clinical Developement And Other Milestone [Member]
Fair Value, Recurring and Nonrecurring [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Other comprehensive income (loss):
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering [Member]
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation cost to be achieved
Number of Operating Segments
Number of operating segment
Debt Securities, Available-for-Sale, Amortized Cost, Current
Contractual maturity of 0 to 1 years, Amortized Cost
Contractual maturity of 0 to 1 years, Amortized Cost
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Research and development and other credits
Research and development and other credits
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Options exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable Ending balance
Income Tax Authority, Name [Domain]
Income Tax Authority, Name
Shares, Outstanding
Balance (in Shares)
Balance (in Shares)
Fair Value Hierarchy and NAV [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested Options Forfeited, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Forfeited or cancelled
Auditor Name
Auditor Name
Fair Value, Inputs, Level 2 [Member]
Level 2 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Lessee, Operating Lease, Description
Operating lease, description
Prior Period Reclassification Adjustment
Prior period reclassification adjustment
Deferred Tax Liabilities, Gross [Abstract]
Deferred income tax liability:
Rule10B 51Trading Plan [Member]
Rule10B 51Trading Plan [Member]
Rule10B 5-1 Trading Plan [Member]
Milestone payment.
Milestone Payment
Milestone payments
Milestone payment received in equity investment measured at fair value.
Milestone Payment Received In Equity Investment Measured At Fair Value
Equity investment measure at fair value
Long-Term Debt, Type [Domain]
Long-term Debt, Type
Open Tax Year
Tax year open for income tax examination
Segment Reporting, Other Segment Item, Amount
Other segment items
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Lessee, Operating Leases [Text Block]
Leases
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Latest Tax Year [Member]
Latest Tax Year [Member]
Number of share options (or share units) exercised via net exercise (cashless) method during the current period.
Cashless Exercise Of Stock Options
Cashless exercise of stock options
Product and Service [Axis]
Product and Service
Adjustments, Noncash Items, to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Gross proceeds from issuable of common stock
Gross Proceeds From Issuable Of Common Stock
Gross proceeds from issuable of common stock.
Noncash Investing and Financing Items [Abstract]
Supplemental disclosures of non-cash transactions:
Deferred Federal, State and Local, Tax Expense (Benefit)
Deferred Federal, State and Local, Tax Expense (Benefit), Total
United States
Cybersecurity Risk Management Processes Integrated [Text Block]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark
Equity [Text Block]
Share Capital
First Renewal Option [Member]
First renewal option.
Title and Position [Axis]
Preferred Stock, Shares Authorized, Unlimited [Fixed List]
Preferred shares, shares authorized
Proceeds from upfront fee.
Proceeds From Upfront Fee
Proceeds from upfront fee
Sale of Stock [Domain]
Sale of Stock
Entity Central Index Key
Entity Central Index Key
Debt Securities, Available-for-Sale [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Warrant [Member]
Warrants
Common stock issued upon conversion of pre-funded warrants
Stock Issued During Period Shares Conversion Of Pre-funded Warrants To Common Shares
Stock issued during period shares conversion of pre-funded warrants to common shares.
Auditor Opinion [Text Block]
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Concentration Risk [Table]
Concentration Risk [Table]
Concentration Risk Disclosure [Text Block]
Concentration of Market Risk
Common Stock, Shares, Issued
Common shares, Issued
XEN496 [Member]
XEN496.
XEN496
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other current assets
Guaranteed investment certificates.
Guaranteed Investment Certificates [Member]
Preferred Stock [Member]
Convertible Preferred Shares [Member]
Income Statement [Abstract]
At -the -market equity offering.
At Market Equity Offering [Member]
At-The-Market Equity Offering [Member]
ATM [Member]
Entity Address, State or Province
Entity Address, State or Province
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Warrants exercise description.
Warrants Exercise Description
Warrants exercise description
Future potential milestone payments.
Future Potential Milestone Payments
Future potential payments
Common stock issued for pre-funded warrants
Common Stock Issued For Pre Funded Warrants
Common stock issued for pre-funded warrants.
Concentration Risk Type [Domain]
Concentration Risk Type
Common shares reserved for issuance
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable, Ending balance
Cover
Cover [Abstract]
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Basic
Net loss per common share - basic
Needham Massachusetts.
Needham Massachusetts [Member]
Term loans.
Term Loans [Member]
Term Loan [Member]
Operating Expenses [Abstract]
Operating expenses:
Document Annual Report
Document Annual Report
Investments, Debt and Equity Securities [Abstract]
Contractual maturity of 0 to 1 years, Unrealized Gain (Loss)
Contractual maturity of 0 to 1 years, Unrealized Gain (Loss)
Debt securities, available-for-sale, accumulated gross unrealized loss, before tax, current.
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax, Current
2014 Amended and restated stock option plan.
Two Thousand Fourteen Amended And Restated Stock Option Plan [Member]
Amended and Restated 2014 Plan [Member]
Share-Based Payment Arrangement, Expense
Stock-based compensation
Pacira biosciences.
Pacira Biosciences [Member]
Pacira BioSciences [Member]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Plan Name [Axis]
Plan Name
Segment Reporting [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Options Outstanding, Ending balance
Number of Options Outstanding, Beginning balance
Number of Options Outstanding
Assets, Current [Abstract]
Current assets:
Potential milestone payments receivable.
Potential Milestone Payments Receivable
Potential milestone payments receivable
Accounting Standards Update and Change in Accounting Principle [Abstract]
Azetukalner
Azetukalner [Member]
Azetukalner.
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Entity Address, Country
Entity Address, Country
Product and Service [Domain]
Product and Service
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Lessee, Operating Lease, Term of Contract
Operating lease term
Concentration Risk [Line Items]
Concentration Risk [Line Items]
Tax Period [Domain]
Tax Period
Operating Loss Carryforwards
Non-capital losses carried forward for tax purposes
Property, Plant and Equipment, Net
Net book value
Property, plant and equipment, net (note 6)
Lessee, Operating Lease, Liability, to be Paid, Year Four
2028
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating activities:
Fair Value, Recurring [Member]
Recurring Basis [Member]
Other Income and Expenses [Abstract]
Other income (expense):
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Current:
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Unrealized fair value gain (loss) on trading securities
Unrealized fair value (gain) loss on trading securities
Debt Securities, Trading, Unrealized Gain (Loss), Total
Debt Securities, Trading, Unrealized Gain (Loss)
Taxes Payable, Current
Taxes Payable, Current, Total
Income and other taxes
Statement of Cash Flows [Abstract]
Counterparty Name [Axis]
Counterparty Name
Antidilutive Securities, Name [Domain]
Preferred Stock, No Par Value
Preferred shares, without par value
Deferred Tax Assets, Other
Other
Equity Components [Axis]
Equity Components
Entity Address, Address Line One
Entity Address, Address Line One
Employee-related Liabilities, Current
Employee compensation, benefits, and related accruals
Employee-related Liabilities, Current, Total
Shares granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Computer Equipment [Member]
Computer Equipment [Member]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Subsequent Event Type [Axis]
Subsequent Event Type
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Nonoperating Income (Expense)
Other income (expense)
Other income (expense)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Antidilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Warrants issued price per pre funded warrant.
Warrants issued price per pre funded warrant
Warrants issued price per pre funded warrant
Price per Pre-Funded Warrant
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Average risk-free interest rate
Debt Securities, Trading
Trading marketable securities
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Accounting Standards Update and Change in Accounting Principle [Text Block]
Changes in Significant Accounting Policies
Entity Voluntary Filers
Entity Voluntary Filers
Amendment Flag
Amendment Flag
Current Income Tax Expense (Benefit)
Current income tax recovery (expense)
Increase (Decrease) in Operating Lease Liability
Operating lease liability
Tax Credit Carryforward, Expiration Date
Tax Credit Carry forward, Expiration Date
Maximum term of each option exercised.
Maximum Term Of Each Option Exercised
Maximum term of each option exercised
Jefferies LLC, Stifel, Nicolaus & Company, Incorporated and Guggenheim Securities, LLC.
Jefferies L L C Stifel Nicolaus Company Incorporated And Guggenheim Securities L L C [Member]
Jefferies, Stifel and Guggenheim Securities, LLC [Member]
Operating Lease, Liability, Noncurrent
Operating lease liability, long-term (note 7)
Corporate Debt Securities [Member]
Additional Paid in Capital, Common Stock
Additional paid-in capital
Debt Securities, Available-for-Sale, Noncurrent
Contractual maturity of 1 to 3 years, Fair Value
Sale of Stock, Price Per Share
Shares price
Net loss for the year
Net loss
Net loss
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Number of Options, Exercised
Exercise of stock options (in Shares)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number of Options Exercisable
Number of Options Exercisable, End of period
Research and Development Expense [Member]
Research and development [Member]
Weighted Average Number Of Common Shares
Weighted average number of common shares.
Common shares (weighted average)
Equity Component [Domain]
Equity Component
Statistical Measurement [Domain]
Statistical Measurement
Document Financial Statement Error Correction [Flag]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
External general and administrative costs
Segment Reporting, Expense Information Used by CODM, Type [Extensible Enumeration]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Furniture and Fixtures [Member]
Office Furniture and Equipment [Member]
Cybersecurity Risk Management Processes Integrated [Flag]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Preferred Stock, Shares Issued
Preferred shares, issued
Collaborate milestone agreement premium related to equity investment.
Collaborate Milestone Agreement Premium Related To Equity Investment
Premium
Operating Lease, Payments
Cash paid for operating lease
Proceeds from exercise of stock options
Proceeds from Stock Options Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Number of Options, Unvested, Beginning balance
Number of Options, Unvested, Ending balance
Payables and Accruals [Abstract]
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Table]
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Class of Stock [Domain]
Class of Stock
Other comprehensive loss (note 6)
Other Comprehensive Income (Loss), Net of Tax, Total
Other Comprehensive Income (Loss), Net of Tax
Other comprehensive (loss) income
Collaborative Arrangement Disclosure [Text Block]
Collaboration Agreements
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Comprehensive loss
Common Stock, Shares, Outstanding
Common shares, Outstanding
Common Stock, Shares, Outstanding, Beginning Balance
Common Stock, Shares, Outstanding, Ending Balance
Second Renewal Option [Member]
Second renewal option.
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Income Tax Recovery (Expense)
Stock option activity.
Stock Option Activity [Abstract]
Antidilutive Securities [Axis]
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Deferred Foreign Income Tax Expense (Benefit)
Canada
Aggregate milestone payment received.
Aggregate Milestone Payment Received
Milestone Payment Received
Collaborative Arrangement and Arrangement Other than Collaborative [Table Text Block]
Schedule Of Collaboration Revenue
Entity Interactive Data Current
Entity Interactive Data Current
Lease Expiration Date
Operating lease expiration date
Subsidiaries [Member]
Xenon Pharmaceuticals USA Inc. [Member]
Product Concentration Risk [Member]
Product Concentration Risk [Member]
Consolidated Entities [Axis]
Consolidated Entities
Pre-funded warrants exercised
Pre-funded Warrants Exercised
Pre-funded warrants exercised.
Related Party Transaction [Domain]
Related Party Transaction
Statistical Measurement [Axis]
Statistical Measurement
Operating Lease, Cost
Operating lease expense
Assets, Fair Value Disclosure, Total
Assets, Fair Value Disclosure
Financial assets
Related and Nonrelated Parties [Domain]
Related Party
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Future Minimum Lease Payments
Significant accounting policies.
Significant Accounting Policies [Line Items]
Significant Accounting Policies [Line Items]
Milestone payment received in cash.
Milestone Payment Received In Cash
Milestone Payment Received in Cash
Commercial Paper [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of restricted share awards, restricted share unit awards or performance awards available for issue
Weighted average grant date fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation expected to be recognized over a period
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Continuing Operations
Effect of exchange rate changes on cash and cash equivalents
Research and Development Expense, Policy [Policy Text Block]
Research and development costs
Statement of Income Location, Balance [Axis]
Income Statement Location
Description of Interest Rate Risk Exposure
Interest rate risk, description
Assets
Total assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Average expected term (in years)
Tax Period [Axis]
Tax Period
Canada
Current Foreign Tax Expense (Benefit)
Income (Loss) from Continuing Operations before Income Taxes, Foreign
United States
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Shares vested
New Accounting Pronouncements, Policy [Policy Text Block]
Recently adopted accounting pronouncements/Accounting pronouncements not yet adopted
Entity Address, City or Town
Entity Address, City or Town
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Loss [Member]
Auditor Location
Auditor Location
December 2023
Pre Funds Warrants Outstanding Date Issuance December Two Thousand Twenty Three [Member]
Pre funds warrants outstanding date issuance december two thousand twenty three.
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Canada and United States revenue agency.
Canada And United States Revenue Agency [Member]
Canada and United States Revenue Agency [Member]
Ian Mortimer [Member]
Ian Mortimer.
Schedule of Segment Reporting Information, by Segment [Table]
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Stock-based compensation
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Accounts Payable, Trade, Current
Accounts payable
Operating Lease, Weighted Average Discount Rate, Percent
Discount rate
Weighted average discount rate
Fair Value Disclosures [Abstract]
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Forfeited, cancelled and expired
Stock Issued During Period, Value, New Issues
Amount offered for issuance of common stock
Issuance of common shares and pre-funded warrants, net (note 9a and note 9e)
Deferred Tax Assets, Net of Valuation Allowance
Net deferred income tax assets
Chief Executive Officer [Member]
Burnaby, British Columbia.
Burnaby British Columbia [Member]
Burnaby, British Columbia [Member]
Stock Issued During Period, Value, Stock Options Exercised
Exercise of stock options
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Liabilities, Current [Abstract]
Current liabilities:
Lease Contractual Term [Axis]
Document Type
Document Type
Investment tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Investment
Deferred tax assets, tax credit carryforwards, investment.
US Government Agencies Debt Securities [Member]
U.S. Government Securities [Member]
Number of share options (or share units) exercised for number of common shares for cash during the period.
Stock Options Exercised For Number Of Common Shares For Cash
Stock Options exercised for Number of Common Shares for cash
Title of 12(b) Security
Title of 12(b) Security
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Clinical development milestones.
Clinical Development Milestones [Member]
Clinical Development Milestones [Member]
Lessee, Operating Lease, Liability, to be Paid, Year Five
2029
Lease, Cost [Table Text Block]
Schedule of Cost Components of Operating Lease
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Document Fiscal Period Focus
Risks Inherent in Servicing Assets and Servicing Liabilities, Type [Domain]
Risks Inherent in Servicing Assets and Servicing Liabilities, Type
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate Intrinsic Value, Exercised
Research and development tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Research
Research and Development Expense
Research and development
Research and Development Expense, Total
Direct external research and development costs
Effective Income Tax Rate Reconciliation, Tax Credit, Research, Amount
Unclaimed Tax Deductions Related To Scientific Research And Experimental Development Expenditures
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Number of Options, Granted
Options granted
Purchases Of Property, Plant And Equipment Included In Accounts Payable And Accrued Liabilities
Purchases of property, plant and equipment included in accounts payable and accrued liabilities.
Purchases of property, plant and equipment included in accounts payable and accrued liabilities
Common Stock, Shares Authorized, Unlimited [Fixed List]
Common shares, shares authorized
Earliest Tax Year [Member]
Earliest Tax Year [Member]
Asset Class [Domain]
Property, Plant and Equipment, Gross
Property, plant and equipment
Property, Plant and Equipment, Gross, Total
Property, Plant and Equipment, Gross, Beginning Balance
Property, Plant and Equipment, Gross, Ending Balance
Subsequent Event Type [Domain]
Subsequent Event Type
Lessee, Leases [Policy Text Block]
Leases
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Fair Value Assumptions for Stock Options
J.P. Morgan, Jefferies, BofA Securities, Inc., Stifel, and RBC Capital Markets, LLC [Member]
Jefferies L L C Stifel Nicolaus Company Incorporated J P Morgan Securities L L C Bof A Securities Inc And R B C Capital Markets L L C [Member]
Jefferies LLC Stifel Nicolaus Company Incorporated J P Morgan Securities LLC BofA Securities Inc and RBC Capital Markets LLC.
Upfront payment received in equity investment.
Upfront Payment Received In Equity Investment
Upfront payment received in equity investment
Regulatory milestone.
Regulatory Milestone [Member]
Regulatory Milestone [Member]
Schedule of property plant and equipment estimated useful lives.
Schedule Of Property Plant And Equipment Estimated Useful Lives Table [Text Block]
Property Plant and Equipment Estimated Useful Lives
Accounting Changes and Error Corrections [Abstract]
Class of Warrant or Right, Exercise Price of Warrants or Rights
Warrants exercise price per common share
Exercise Price
Financial Instruments [Domain]
Unrealized foreign exchange (gain) loss
Unrealized Gain (Loss), Foreign Currency Transaction, before Tax
March 2021
Pre Funds Warrants Outstanding Date Issuance March Two Thousand Twenty One [Member]
Pre funds warrants outstanding date issuance march two thousand twenty one.
Cash received for lease incentives
Cash received for lease incentives
Cash received for lease incentives.
Provincial tax credit.
Provincial Tax Credit [Member]
Provincial Tax Credit [Member]
Sale of Stock [Axis]
Sale of Stock
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing activities:
Category of Item Purchased [Axis]
Category of Item Purchased
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items]
Marketable Securities, Current
Marketable securities (note 5)
Interest Receivable and Accretion Of Discounts On Marketable Securities
Interest Receivable and Accretion Of Discounts On Marketable Securities
Interest receivable and accretion of discounts on marketable securities
Interest receivable and accretion of discounts on marketable securities
Income Tax Disclosure [Text Block]
Income Taxes
Number of common stock issued in exchange for share options (or share units) exercised via net exercise (cashless) method during the current period.
Common Stock Issued For Cashless Exercise
Common stock issued for cashless exercise
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Effective Income Tax Rate Reconciliation
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Consolidated Entities [Domain]
Consolidated Entities
Foreign Currency Exchange Rate, Translation
Foreign exchange rate translation
Unrealized Gain (Loss)
Available For Sale Debt Securities Accumulated Gross Unrealized Gain (Loss) Before Tax
Available for sale debt securities accumulated gross unrealized gain (loss) before tax.
Debt Securities, Available-for-Sale [Table]
Depreciation, Depletion and Amortization, Nonproduction
Depreciation, Depletion and Amortization, Nonproduction, Total
Depreciation of property, plant and equipment
Other Accrued Liabilities, Current
Other
Liabilities and Equity [Abstract]
Liabilities and shareholders’ equity
Document Period End Date
Document Period End Date
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Other non-deductible expenses
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Effective income tax rate
Effective Income Tax Rate Reconciliation, Percent
Stockholders' Equity Note [Abstract]
Royalty obligations.
Royalty Obligations
Royalty obligations
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Antidilutive securities excluded from computation of EPS
Neurocrine biosciences.
Neurocrine Biosciences [Member]
Neurocrine Biosciences [Member]
Lessee, Operating Lease, Liability, to be Paid, after Year Five
2030 and thereafter
Other Research and Development Expense
Other research and development costs
Stock Issued During Period Value Conversion Of Pre Funded Warrant
Stock issued during period value conversion of pre funded warrant.
Conversion of pre-funded warrants (note 9e)
Income tax recovery (expense) (note 13)
Income Tax Expense (Benefit)
Income tax expense (recovery)
Income tax recovery (expense)
Income Tax Authority, Name [Axis]
Income Tax Authority, Name
Trading Symbol
Trading Symbol
Equity, Attributable to Parent
Balance
Balance
Total shareholders' equity
Document Financial Statement Restatement Recovery Analysis [Flag]
Fair value assumptions for stock options.
Fair Value Assumptions For Stock Options [Abstract]
Contractual maturity of 1 to 3 years, Unrealized Gain (Loss)
Contractual maturity of 1 to 3 years, Unrealized Gain (Loss)
Debt securities, available-for-sale, accumulated gross unrealized loss, before tax, noncurrent
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax, Noncurrent
Deferred Tax Assets, Gross
Total deferred income tax assets
BVF Partners L P.
B V F Partners L P [Member]
BVF Partners L.P [Member]
Fair value of pre-funded warrants exercised
Fair value of pre-funded warrants exercised
Fair Value Of Pre-funded Warrants Exercised
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Outstanding, ending
Outstanding, beginning
Class of Warrant or Right, Outstanding
Share-Based Payment Arrangement [Policy Text Block]
Stock-based compensation
Variable Lease, Cost
Variable lease expense
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Cybersecurity Risk Management, Strategy, and Governance [Table]
Aggregate price of transaction allocated to performance obligations
Aggregate Price Of Transaction Allocated To Performance Obligations
Transaction price allocated to performance obligations
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Unrecognized stock-based compensation cost not to be achieved
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Stock Based Compensation Expenses
Deferred Income Tax Expense (Benefit)
Deferred income tax recovery (expense)
Deferred income tax recovery
Other milestones.
Other Milestones [Member]
Other Milestones [Member]
Geographical [Axis]
Geographical
PSUs
Phantom Share Units (PSUs) [Member]
Amount of deferred tax asset attributable to taxable temporary differences from deferred financing costs.
Deferred Tax Assets Deferred Financing Fees
Deferred financing fees
Unrealized Gain (Loss)
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Loss
Leases [Abstract]
Use of Estimates, Policy [Policy Text Block]
Use of estimates
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and cash equivalents
Stock Issued During Period, Value, Conversion of Convertible Securities
Conversion of preferred shares (note 9d)
APIC, Share-Based Payment Arrangement, Option, Increase for Cost Recognition
Stock-based compensation expense (note 9c)
Deferred Tax Liabilities, Leasing Arrangements
Operating lease right-of-use-asset
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend yield
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Trading Activity [Axis]
Trading Activity
Security Exchange Name
Security Exchange Name
Counterparty Name [Domain]
Counterparty Name
Operating Expenses
Total operating expenses
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Vested
Tax attributes expired/utilized
Effective Income Tax Rate Reconciliation, Tax Attributes Expired Or Utilized
Effective income tax rate reconciliation, tax attributes expired or utilized.
Tax attributes expired/utilized
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Class of Stock [Axis]
Class of Stock
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less: accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Fair Value Disclosures [Text Block]
Fair Value of Financial Instruments
Lessee, Operating Lease, Liability, to be Paid, Year Three
2027
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Granted
Weighted average fair value of options granted
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
Subsequent Event [Member]
Subsequent Event [Member]
Maximum [Member]
Maximum [Member]
Liabilities and Equity
Total liabilities and shareholders’ equity
Operating Lease, Right-of-Use Asset
Operating lease right-of-use asset, net (note 7)
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Number of Options, Vested
Supplemental Cash Flow Information [Abstract]
Supplemental disclosures:
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Diluted
Net loss per common share - diluted
Leasehold Improvements [Member]
Leasehold Improvements [Member]
Liabilities
Total liabilities
Upfront payment in cash.
Upfront Payment In Cash
Upfront payment received in cash
Fair Value Hierarchy and NAV [Domain]
Assets, Current
Total current assets
Net Cash Provided by (Used in) Investing Activities
Net cash provided by (used in) investing activities
Stock Issued During Period, Shares, New Issues
Shares issued
Issuance of common shares and pre-funded warrants, net (note 9a and note 9e) (in shares)
Unrecognized Tax Benefits
Unrecognized tax benefits of uncertain tax positions
Unrecognized Tax Benefits, Beginning Balance
Unrecognized Tax Benefits, Ending Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Option, Nonvested, Weighted Average Exercise Price
Weighted Average Grant Date Fair Value, Unvested, Ending balance
Weighted Average Grant Date Fair Value, Unvested, Beginning balance
Change in valuation allowance
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Entity Filer Category
Entity Filer Category
Deferred Tax Assets, Property, Plant and Equipment
Depreciable assets
Property, Plant and Equipment [Abstract]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right
Warrants outstanding to purchase common stock
Pre-Funded Warrants to Purchase Common Shares
Debt Securities, Available-for-Sale, Amortized Cost, Noncurrent
Contractual maturity of 1 to 3 years, Amortized Cost
Contractual maturity of 1 to 3 years, Amortized Cost
Prepaid Expense, Noncurrent, Total
Prepaid Expense, Noncurrent
Prepaid expenses, long-term
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Nature of the business
Payments to Acquire Marketable Securities
Purchase of marketable securities
Current Fiscal Year End Date
Current Fiscal Year End Date
Financial Assets Measured at Fair Value on a Recurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Property, Plant and Equipment, Policy [Policy Text Block]
Property, plant and equipment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Aggregate fair value of options vested
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: imputed interest
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation
Share-Based Payment Arrangement, Noncash Expense, Total
stock-based compensation
Related Party Transaction [Axis]
Related Party Transaction
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Schedule of Earnings Per Share, Basic, by Common Class, Including Two Class Method [Table Text Block]
Schedule of Basic and Diluted Net Loss Per Common Share
Related and Nonrelated Parties [Axis]
Related Party
Contractual maturity of 0 to 1 years, Unrealized Gain (Loss)
Debt Securities Available For Sale Accumulated Gross Unrealized Gain (Loss) Before Tax Current
Debt securities available for sale accumulated gross unrealized gain (loss) before tax current
Entity Registrant Name
Entity Registrant Name
Amended and restated stock option plan.
Amended And Restated Stock Option Plan [Member]
Amended and Restated Stock Option Plan [Member]
Trading Activity, by Type [Domain]
Trading Activity, by Type
Two thousand nineteen inducement equity incentive plan.
Two Thousand Nineteen Inducement Equity Incentive Plan [Member]
2019 Inducement Plan [Member]
Preferred Stock, Conversion Basis
Preferred shares convertible into common shares
Number of Reportable Segments
Number of reportable segments
June 2022
Pre Funds Warrants Outstanding Date Issuance June Two Thousand Twenty Two [Member]
Pre funds warrants outstanding date issuance june two thousand twenty two.
Change in Accounting Principle, Accounting Standards Update, Early Adoption [true false]
Change in accounting principle, early adoption
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Earnings Per Share [Text Block]
Net Loss Per Common Share
Entity Emerging Growth Company
Entity Emerging Growth Company
Weighted Average Number of Shares Outstanding, Basic
Basic
Weighted average common shares outstanding - basic
Weighted average common shares outstanding - basic
1st Order Pharmaceuticals, Inc.
First Order Pharmaceuticals Inc [Member]
1st Order Pharmaceuticals, Inc. [Member]
Lessee, Operating Lease, Option to Terminate
Operating lease, option to terminate
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Interest Rate Risk [Member]
Interest Rate Risk [Member]
Property, Plant and Equipment, Useful Life
Property, Plant and Equipment, Useful Life
Proceeds from Issuance of Common Stock
Amount offered for issuance of common stock
Sale proceeds of common shares
Proceeds from Sale and Maturity of Marketable Securities
Proceeds from marketable securities
Concentration Risk Type [Axis]
Concentration Risk Type
Fair Value, Inputs, Level 1 [Member]
Level 1 [Member]
Operating lease, number of renewal options
Lessee Operating Lease Number of Renewal Options
Lessee operating lease number of renewal options.
Milestone payment due on initiation of Phase 1b clinical trial.
Milestone Payment Due On Initiation Of Phase1b Clinical Trial
Milestone payment due on initiation of Phase 1b clinical trial
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Increase (Decrease) in Accounts Payable and Accrued Liabilities, Total
Accounts payable and accrued liabilities
Debt Disclosure [Abstract]
Documents Incorporated by Reference [Text Block]
Documents Incorporated by Reference
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
Rule10B 51Trading Plan One [Member]
Rule10B 51Trading Plan One [Member]
Rule10B 5-1 Trading Plan One [Member]
Financial Instrument [Axis]
Research equipment.
Research Equipment [Member]
Research Equipment [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Options Outstanding Weighted Average Remaining Contractual Life in Years
Net income (loss) per common share
Earnings Per Share, Policy [Policy Text Block]
Long-Term Purchase Commitment, Category of Item Purchased [Domain]
Long-term Purchase Commitment, Category of Item Purchased
Medpace clinical development service agreement.
Medpace Clinical Development Service Agreement [Member]
Priority Access Agreement with Medpace Inc. [Member]
Schedule of Nonvested Share Activity [Table Text Block]
Schedule of Unvested Stock Option Activity
General and Administrative Expense [Member]
General and administrative [Member]
License and Collaboration Agreement.
License And Collaboration Agreement [Member]
License and Collaboration Agreement [Member]
Impairment, Long-Lived Asset, Held-for-Use
Impairment of Long-Lived Assets
Impairment, Long-Lived Asset, Held-for-Use, Total
Impairment charges recognized
Revenue [Policy Text Block]
Revenue recognition
Share-Based Payment Arrangement [Abstract]
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of long-lived assets
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Jefferies LLC and Stifel, Nicolaus & Company, Incorporated member.
Jefferies L L C And Stifel Nicolaus Company Incorporated [Member]
Jefferies and Stifel [Member]
Jefferies and Stifel [Member]
Jefferies, Stifel, J.P. Morgan Securities LLC and SVB Securities LLC [Member]
Jefferies L L C Stifel Nicolaus Company Incorporated J P Morgan Securities L L C And S V B Securities L L C [Member]
Jefferies L L C, Stifel Nicolaus Company Incorporated, J.P.Morgan Securities LLC and SVB Securities LLC.
Proceeds from Issuance of Warrants
Sale proceeds from issuance of pre funded warrants
Share Capital [Table]
Share capital.
Share Capital [Table]
Cybersecurity Risk Role of Management [Text Block]
Weighted Average Number Of Prefunded Warrants
Weighted average number of prefunded warrants.
Pre-funded warrants (weighted average)
Debt Securities, Available-for-Sale, Total
Debt Securities, Available-for-Sale
Fair Value
Trading securities available-for-sale
Accounting Policies [Abstract]
Stock Issued During Period Common Shares Cancelled
Stock issued during period common shares cancelled.
Shares cancelled
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Stock Option Activity
Income Tax Disclosure [Abstract]
Marketable Securities, Noncurrent
Marketable securities, long-term (note 5)
Equity, Attributable to Parent [Abstract]
Shareholders’ equity:
Variable consideration allocated to performance obligation.
Variable Consideration Allocated To Performance Obligation
Variable consideration allocated to performance obligation
Change in Accounting Principle, Accounting Standards Update, Transition Option Elected [Extensible Enumeration]
Change in Accounting Principle, Accounting Standards Update, Transition Option Elected [Extensible Enumeration]
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other
Series 1 preferred shares.
Series1 Preferred Shares [Member]
Series1 Preferred Shares
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Line Items]
Statement [Table]
Statement [Table]
Segment Reporting, Policy [Policy Text Block]
Segment and geographic information
Property, Plant and Equipment [Table Text Block]
Summary of Property, Plant and Equipment
Schedule Of Pre-Funded Warrants Activity
Schedule Of Pre Funded Warrants Activity [Table Text Block]
Schedule of pre funded warrants activity.
Jefferies LLC SVB leerink LLC and stifel nicolaus company incorporated.
Jefferies L L C S V B Leerink L L C And Stifel Nicolaus Company Incorporated [Member]
Jefferies LLC SVB Leerink LLC and Stifel Nicolaus Company Incorporated [Member]
Revenue from Contract with Customer, Including Assessed Tax
Revenue
Total revenue
Revenue (note 10)
Entity File Number
Entity File Number
Segment
Segment Reporting Disclosure [Text Block]
Increase (decrease) in cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Servicing Assets and Servicing Liabilities Risk [Axis]
Servicing Assets and Servicing Liabilities Risk
Earnings Per Share [Abstract]
Net loss per common share (note 11):
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock based compensation
Lease Contractual Term [Domain]
Investment Tax Credit Carryforward [Member]
Investment Tax credit [Member]
Statement of Financial Position [Abstract]
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
License and Service [Member]
Collaboration Revenue [Member]
Entity Incorporation, Date of Incorporation
Date of incorporation
Operating Income (Loss)
Loss from operations
Shares Issued, Price Per Share
Aggregate purchase price per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Common Stock, No Par Value
Common shares, without par value
Entity Shell Company
Entity Shell Company
Unfavorable change in interest rates of marketable securities.
Unfavorable Change In Interest Rates Of Marketable Securities
Unfavorable change in interest rates of marketable securities
Accrued Professional Fees, Current
Professional fees
Basis of presentation.
Basis Of Presentation [Line Items]
Basis of Presentation [Line Items]
Entity Tax Identification Number
Entity Tax Identification Number
Assets [Abstract]
Assets
Fair Value of Financial Instruments, Policy [Policy Text Block]
Financial instruments and fair value
Entity Current Reporting Status
Entity Current Reporting Status
Net Income (Loss) Available to Common Stockholders, Basic
Net loss attributable to common shareholders
Net loss per common share - basic
Net loss attributable to common shareholders
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Options Exercisable Weighted Average Remaining Contractual Life in Years
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]
Accounts Payable and Accrued Liabilities
Property, Plant and Equipment Disclosure [Text Block]
Property, Plant and Equipment
Long-Term Debt, Type [Axis]
Long-term Debt, Type
Geographical [Domain]
Geographical
Document Fiscal Year Focus
Document Fiscal Year Focus
Cash, Cash Equivalents, and Short-Term Investments
Cash and cash equivalents and marketable securities
Cash, Cash Equivalents, and Short-Term Investments, Total
Collaborate agreement premium related to equity investment.
Collaborate Agreement Premium Related To Equity Investment
Collaborate agreement premium related to equity investment
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in accounting principle, adoption date
Other General and Administrative Expense
Other general and administrative costs
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period
Number of Options, Forfeited, cancelled or expired
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures and Expirations in Period, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares [Roll Forward]
Recognition of transaction price.
Recognition Of Transaction Price
Recognition of the transaction price
Performance obligation related to milestone
Performance Obligations Related To Milestone
Performance obligations in relation to this milestone.
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash and cash equivalents, end of year
Cash and cash equivalents, beginning of year
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Proceeds from public offerings, net
Proceeds from Issuance Initial Public Offering
Tax Credit Carryforward, Amount
Tax credit available to offset taxes payable
City Area Code
City Area Code
Liabilities, Current
Total current liabilities
Percentage of option to fund development costs upon achievement of certain milestones.
Percentage Of Option To Fund Development Costs Upon Achievement Of Certain Milestones
Percentage of option to co-fund development costs upon achievement of certain milestones
Legal Costs, Policy [Policy Text Block]
Intellectual property
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Canadian federal and provincial tax rates
Tax at statutory income tax rate
Stock Issued During Period, Shares, Conversion of Convertible Securities
Conversion of shares
Conversion of preferred shares (note 9d) (in shares)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Preferred Stock, Shares Outstanding
Preferred shares, outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Pre-clinical Discovery And Other Programs [Member]
Pre-clinical discovery and other programs.
Pre-clinical, discovery and other programs
Income Tax, Policy [Policy Text Block]
Income taxes
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of Loss before Income Taxes
Commitments and Contingencies Disclosure [Abstract]
Foreign Exchange [Member]
Foreign Currency Exchange Risk [Member]
Basis of Accounting [Text Block]
Basis of Presentation
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Amortized Cost
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Net Deferred Income Tax Assets
Operating Lease, Liability, Current
Operating lease liability (note 7)
Retained Earnings [Member]
Accumulated Deficit [Member]
Over-Allotment Option [Member]
Over Allotment [Member]
Payments to Acquire Property, Plant, and Equipment
Purchases of property, plant and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Accrued Liabilities, Current [Abstract]
Accrued Liabilities
Milestone payments paid.
Milestone Payments Paid
Milestone payment paid
Document Transition Report
Document Transition Report
Contractual maturity of 1 to 3 years, Unrealized Gain (Loss)
Debt Securities Available For Sale Accumulated Gross Unrealized Gain (Loss) Before Tax Noncurrent
Debt securities available for sale accumulated gross unrealized gain (loss) before tax noncurrent.
Lessee, Operating Lease, Liability, to be Paid, Year Two
2026
Antidilutive Security, Excluded EPS Calculation [Table]
Milestone payment received in equity investment.
Milestone Payment Received In Equity Investment
Milestone Payment Received in Equity Investment
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of credit risk:
Deferred tax assets (note 13)
Deferred Income Tax Assets, Net
Personnel Related Expenses
Personnel related expenses.
Personnel-related expenses
Auditor Firm ID
Auditor Firm ID
Minimum [Member]
Minimum [Member]
Common Stock [Member]
Common Shares [Member]
Common Shares [Member]
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Accounts Payable and Accrued Liabilities
Operating Lease, Right-of-Use Asset, Periodic Reduction
Non-cash operating lease expense
Additional Paid-in Capital [Member]
Additional Paid-in Capital [Member]
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Debt Securities, Available-for-Sale, Current
Contractual maturity of 0 to 1 years, Fair Value
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign currency translation
Statement of Income Location, Balance [Domain]
Income Statement Location
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
Asset purchase agreement.
Asset Purchase Agreement [Member]
Asset Purchase Agreement [Member]
Issued
Number Of Warrants Issued
Number of warrants issued.
Cash and money market fund.
Cash and Money Market Fund [Member]
Increase (Decrease) in fair value of marketable securities.
Increase Decrease In Fair Value Of Marketable Securities
Decrease in the fair value of marketable securities
Performance Shares [Member]
PSUs
Current Federal, State and Local, Tax Expense (Benefit)
Current Federal, State and Local, Tax Expense (Benefit), Total
United States
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested Options Forfeited, Number of Shares
Number of Options, Forfeited or cancelled
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
Title and Position [Domain]
Segment Reporting, Expense Information Used by CODM, Description
Segment Reporting, Expense Information Used by CODM, Description
Basis of presentation.
Basis Of Presentation [Table]
Basis Of Presentation [Table]
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Canada
Common Stock, Value, Issued
Common shares, without par value; unlimited shares authorized; issued and outstanding: 76,416,086 (December 31, 2023 - 75,370,977) (note 9)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Share capital.
Share Capital [Line Items]
Share Capital [Line Items]
Investment Income, Interest
Interest income
Interest income
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents
Revenue from Contract with Customer Benchmark [Member]
Total Revenues [Member]
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Financial Assets Measured at Fair Value on a Recurring Basis
Accrued Research and Development, Current
Accrued research and development, current.
Research and development
Net income (loss) available to preferred stockholders basic.
Net Income Loss Available To Preferred Stockholders Basic
Net loss attributable to preferred shareholders
Net Income Loss Available To Preferred Stockholders Basic, Total
Operating Lease, Liability
Present value of lease liabilities
Operating Lease, Liability, Total
Summary of Amortized Cost, Unrealized Gain (Losses) Recognized in AOCI and Fair Value of Available-for-Sale Securities
Debt Securities, Available-for-Sale [Table Text Block]
Measurement Frequency [Axis]
Deferred Tax Assets, Operating Loss Carryforwards
Non-capital losses
Deferred Tax Assets, Operating Loss Carryforwards, Total
Commitments and contingencies (note 12)
Commitments and Contingencies
Research and development services.
Research And Development Services
Research and development services
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Diluted
Weighted average common shares outstanding - diluted
Significant Accounting Policies [Text Block]
Significant accounting policies
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Summary of Net Loss Related To Segment Expenses
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Exercised
Number of warrants exercised.
Number Of Warrants Exercised
Exercise of pre-funded warrants
Lessee, Operating Lease, Renewal Term
Operating lease extension term
Lessee, Operating Lease, Liability, to be Paid
Total future minimum lease payments
Cybersecurity Risk Management Third Party Engaged [Flag]
Exchange agreement.
Exchange Agreement [Member]
Exchange Agreement [Member]
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Significant accounting policies.
Significant Accounting Policies [Table]
Significant Accounting Policies [Table]
Concentration Risk Benchmark [Domain]
Concentration Risk Benchmark
Entity Small Business
Entity Small Business
Segment Reporting Information [Line Items]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Sales-based milestone.
Sales Based Milestone [Member]
Sales Based Milestone [Member]
Debt Disclosure [Text Block]
Term Loan
US Treasury Securities [Member]
U.S. Treasuries [Member]
Foreign exchange gain (loss)
Gain (Loss), Foreign Currency Transaction, before Tax
Foreign Currency Transaction Gain (Loss), before Tax, Total
Foreign exchange (loss) gain
Commitments and contingencies.
Commitments And Contingencies [Table]
Commitments And Contingencies [Table]
Lessee, number of operating leases.
Lessee Number Of Operating Leases
Number of operating leases
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price Outstanding, Ending balance
Weighted Average Exercise Price Outstanding, Beginning balance
Options Outstanding, Weighted Average Exercise Price
Weighted-average common shares outstanding (note 4):
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]
Operating lease liability
Deferred Tax Assets, Operating Lease Liability
Deferred tax assets, operating lease liability.
Asset Class [Axis]
Deferred Tax Assets, Gross [Abstract]
Deferred income tax assets:
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use asset obtained in exchange for new operating lease liability
Measurement Frequency [Domain]
Deferred Tax Assets, Valuation Allowance
Less - valuation allowance
Fair Value, Inputs, Level 3 [Member]
Level 3 [Member]
Operating Lease, Weighted Average Remaining Lease Term
Remaining lease term (years)
Weighted average remaining lease term (years)
Stock Issued During Period Shares Conversion Of Pre Funded Warrant
Stock issued during period shares conversion of pre funded warrant.
Conversion of pre-funded warrants (note 9e) (in shares)
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Unrealized gain (loss) on available-for-sale securities (note 5)
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
The aggregate grant-date fair value of stock options exercised via net exercise (cashless) during the reporting period as calculated by applying the disclosed option pricing methodology.
Fair Value Of Stock Options Exercised On Cashless Basis
Fair value of stock options exercised on a cashless basis
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in accounting principle, material impact
Risks and Uncertainties [Abstract]
Commitments and contingencies.
Commitments And Contingencies [Line Items]
Commitments And Contingencies [Line Items]
Accounts Payable and Accrued Liabilities, Current
Total
Accounts payable and accrued liabilities (note 8)
October 2021
Pre Funds Warrants Outstanding Date Issuance October Two Thousand Twenty One [Member]
Pre funds warrants outstanding date issuance october two thousand twenty one.