SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL OMB Number: 3235-0104 Estimated average burden hours per response: 0.5

1. Name and Address of Reporting Person* Machado Patrick (Last) (First) (Middle) 200 - 3650 GILMORE WAY (Street) BURNABY A1 V5G 4W8 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 11/05/2020	3. Issuer Name and Ticker or Trading Symbol Xenon Pharmaceuticals Inc. [ XENE ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) X Director 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
No securities are beneficially owned	0	D(1)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
No securities are beneficially owned	(1)	(1)	N/A(1)	(1)	0.00	D

Explanation of Responses:

1. Not applicable

Remarks:

Exhibit Index: 24.1 Power of Attorney

	/s/ Cassandra Robinson, Attorney-in-fact	11/05/2020
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

				POWER OF ATTORNEY

       The undersigned, as a Section 16 reporting person of Xenon
Pharmaceuticals Inc. (the "Company"), hereby constitutes and appoints each of
the responsible attorneys and paralegals of Wilson Sonsini Goodrich & Rosati,
Professional Corporation, specifically Barbara Mery of Wilson Sonsini Goodrich &
Rosati, Professional Corporation, and each of Emmanuelle Vallee, Sherry Aulin,
Barbara Filice and Cassandra Robinson of the Company, the undersigned's true and
lawful attorney-in-fact to:

	1. complete and execute Forms ID, 3,4 and 5 and other forms and all amendments
	thereto as such attorney-in-fact shall in his or her discretion determine to be
	required or advisable pursuant to Section 16 of the Securities Exchange Act of
	1934 ( as amended) and the rules and regulations promulgated thereunder, or any
	successor laws and regulations, as a consequence of the undersigned's
	ownership, acquisition or disposition of securities of the Company; and

	2. do all acts necessary in order to file such forms with the Securities and
	Exchange Commission, any securities exchange or national association, the
	Company and such other person or agency as the attorney-in-fact shall deem
	appropriate.

       The undersigned hereby ratifies and confirms all that said
attorneys-in-fact and agents shall do or cause to be done by virtue hereof. The
undersigned acknowledges that the foregoing attorneys-in-fact, in serving in
such capacity at the request of the undersigned, are not assuming, nor is the
Company assuming, any of the undersigned's responsibilities to comply with
Section 16 of the Securities Exchange Act of 1934 (as amended).

       This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Forms ID, 3, 4 and 5 with respect to
the undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing delivered
to the Company and the foregoing attorneys-in-fact.

       IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this 29th day of October, 2020.


								Signature:   /s/ Patrick Machado
             								     Patrick Machado