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|Positive Preclinical Data from Xenon’s XEN901 Epilepsy Program to be Presented at the 71st American Epilepsy Society Annual Meeting|
XEN901 is a potent, selective Nav1.6 sodium channel inhibitor being developed by Xenon for the treatment of epilepsy, including treatment resistant adult focal seizures and rare, pediatric forms of epilepsy, such as EIEE13, an early infantile epileptic encephalopathy associated with mutations in the SCN8A gene and gain-of-function in the Nav1.6 sodium channel.
Xenon has examined XEN901 in preclinical models of both genetically defined and more general types of epilepsy. These studies showed that XEN901 demonstrated efficacy against seizures in both the MES model, which is designed to be predictive of adult focal seizures and an SCN8A Nav1.6 genetic gain-of-function model, which is designed to be predictive of the pediatric genetic epilepsy EIEE13. When compared to phenytoin in the SCN8A model, XEN901 achieved the same degree of efficacy as phenytoin at one thousand fold lower brain exposures.
Xenon expects to file an investigational new drug equivalent application in the fourth quarter of 2017 in order to initiate clinical development for XEN901 and, if supported by the data, expects to initiate a Phase 2 clinical trial in late 2018.
Xenon is a clinical stage biopharmaceutical company focused on developing innovative therapeutics to improve the lives of patients with neurological disorders. Building upon our extensive knowledge of human genetics and diseases caused by mutations in ion channels, known as channelopathies, we are advancing – both independently and with our pharmaceutical collaborators – a novel product pipeline of ion channel modulators to address therapeutic areas of high unmet medical need, such as pain and epilepsy. For more information, please visit www.xenon-pharma.com.
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